Greg, the main character played by Thomas Mann, is a quirky teen who finds a way to skirt by without much notoriety in high school. He is committed to avoiding meaningful social interactions in an effort to not be associated with any one clique. Rachel, played by Olivia Cooke, is one of his classmates to whom he pays little attention until his mother forces him to hang out with her after learning she has cancer. Lastly, Earl is one of Greg's best friends from when they were very young. Other than Rachel, Earl is the only other character Greg is seen with alone on screen, excluding his parents. Each of these are fantastic roles that show the committment to their background and development. This committment and strong characteriziation is extremely prevelant in the main single shots lasting longer than expected. The one that comes to mind is the bedroom scene when Rachel has decides to stop seeking treatment and brings Greg in on that decision.
While dealing with cancer of a forced friend, the film manages to carry a lightness. The use of Greg's voice journalizing the entire movie helps the audience stomach the cancer of a close friend. It allows you to see through his eyes and take in all interactions he faces no matter how big or small. The playful cinematography is a strong parallel for how Greg actually is, with his dry humor and unique perspective on just about everything. While it does make sense to feature this type of camera handling, it is somewhat distracting with frequent movement and 180's that seem unneccesary.

Overall, I am pleasantly surprised with this film. I recommend it to all ages. It's a unique perspective that is not overdone or romanticized. From scissors, to squirrels and pillows, Me and Earl and the Dying Girl is presenting a slightly maturing version of Juno consistent with the Indie feel although a major motion picture.